DEVELOPMENT, CHARACTERIZATION, AND EVALUATION OF SELEGILINE BIONANOSUSPENSIONS USING BUCHANANIA LANZAN AS BIOSTABILIZER

Objective: Development and evaluation of selegiline-loaded bio-nanosuspensions using biopolymer which was isolated from seeds of Buchanania lanzan (Chironji), used as biostabilizer and compared with standard polymer. Methods: The selegiline-loaded bio-nanosuspensions were prepared using novel biopolymer and standard stabilizer (hydroxypropyl methylcellulose) by sonication solvent evaporation method with different ratios (1%, 2%, 3%, 4%, and 5%) and evaluated for particle size, polydispersity index, zeta potential, pH stability studies, percentage entrapment efficacy, in vitro drug release, and stability studies. Results: The prepared selegiline bio-nanosuspensions were subjected to the best formulation based on comparison of above-mentioned evaluation parameters, so Fb2 (2%) formulation was found to be the best formulation showing an R2=0.9842, T50% of 32 h and T80% of 70 h, respectively. According to the release kinetics, the best fit model was found to be Peppas-Korsmeyer with Fickian diffusion (Higuchi matrix) as the mechanism of drug release, and Fs5 (5%) formulation was found to be the best formulation showing an R2=0.9564, T50% of 25 h and T80% of 60 h, respectively. According to the release kinetics, the best fit model was found to be Peppas-Korsmeyer with Fickian diffusion (Higuchi matrix) as the mechanism of drug release. The biopolymer provided excellent stability for the formulation and resulting particle size for the best formulation was found to be 360 nm. The best formulation was found to be polydispersity index of 0.43 with zeta potential of −5.12 mV. Conclusion: The prepared bio-nanosuspensions using biopolymer were found to be safe and compatible with the novel drug delivery for the treatment of depression in comparison of standard polymer

Smart ungual biopenetrant from the roots of Beta vulgaris

The main objective of the current research was to isolate biopenetrant from Beta vulgaris and formulate bioadhesive layers loaded with terbinafine using this biopenetrant for delivery through nail. Form the preparation of films, Rosa centifolia and Vitis vinifera were used as a biopolymer. Beta vulgaris was used as biopenetrant. The formulations prepared using Beta vulgaris biopenetrant were compared with formulations containing papain as standard penetrant. Four bio-adhesive films of different ratios were prepared by film casting method using each penetrant. The formulated films were evaluated for various parameters like weight, thickness, nail adhesivity, content uniformity, surface pH, folding endurance, and in-vitro drug permeation. The formulation LB4 (containing 1:4 Beta vulgaris biopenetrant) was found to be the best formulation having R2 value 0.990 with zero order as best fit model. The results obtained conclude that biopenetrants can be used as natural penetration enhancer